Compile Data Set for Download or QSAR
Report error Found 459 Enz. Inhib. hit(s) with all data for entry = 6859
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154708(US8999957, Table 2, Compound 45)
Affinity DataKd:  0.0100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154710(US8999957, Table 2, Compound 47)
Affinity DataKd:  0.0200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154709(US8999957, Table 2, Compound 46)
Affinity DataKd:  0.0300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154670(US8999957, Table 2, Compound 7)
Affinity DataKd:  0.0520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154713(US8999957, Table 2, Compound 50)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154698(US8999957, Table 2, Compound 35)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154699(US8999957, Table 2, Compound 36)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154694(US8999957, Table 2, Compound 31)
Affinity DataKd:  0.130nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154680(US8999957, Table 2, Compound 17)
Affinity DataKd:  0.150nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154692(US8999957, Table 2, Compound 29)
Affinity DataKd:  0.200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154681(US8999957, Table 2, Compound 18)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154696(US8999957, Table 2, Compound 33)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154673(US8999957, Table 2, Compound 10)
Affinity DataKd:  0.220nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154687(US8999957, Table 2, Compound 24)
Affinity DataKd:  0.240nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154720(US8999957, Table 2, Compound 59)
Affinity DataKd:  0.260nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154682(US8999957, Table 2, Compound 19)
Affinity DataKd:  0.270nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154706(US8999957, Table 2, Compound 43)
Affinity DataKd:  0.280nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154634(US8999957, Table 1, Compound 2)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154711(US8999957, Table 2, Compound 48)
Affinity DataKd:  0.390nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154665(US8999957, Table 2, Compound 2)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154666(US8999957, Table 2, Compound 3)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154712(US8999957, Table 2, Compound 49)
Affinity DataKd:  0.420nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154675(US8999957, Table 2, Compound 12)
Affinity DataKd:  0.480nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154667(US8999957, Table 2, Compound 4)
Affinity DataKd:  0.5nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154674(US8999957, Table 2, Compound 11)
Affinity DataKd:  0.510nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154669(US8999957, Table 2, Compound 6)
Affinity DataKd:  0.520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154691(US8999957, Table 2, Compound 28)
Affinity DataKd:  0.530nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154635(US8999957, Table 1, Compound 3)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154700(US8999957, Table 2, Compound 37)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154612(US8999957, Column 165-167, Compound 1)
Affinity DataIC50: 0.600nMAssay Description:Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154676(US8999957, Table 2, Compound 13)
Affinity DataKd:  0.660nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154596(US8999957, Column 152, Compound 1)
Affinity DataKd:  0.800nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154664(US8999957, Table 2, Compound 1)
Affinity DataKd:  0.810nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154688(US8999957, Table 2, Compound 25)
Affinity DataKd:  0.830nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154685(US8999957, Table 2, Compound 22)
Affinity DataKd:  0.900nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154719(US8999957, Table 2, Compound 57)
Affinity DataKd:  0.970nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154863(US8999957, Table 3, Compound 136)
Affinity DataIC50: 1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154874(US8999957, Table 3, Compound 147)
Affinity DataIC50: 1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154864(US8999957, Table 3, Compound 137)
Affinity DataIC50: 1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 1.10nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 1.10nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154613(US8999957, Column 165-167, Compound 2)
Affinity DataIC50: 1.10nMAssay Description:Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

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