Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 6899
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 207nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 263nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 338nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US9029356, 26 | US9255087, 26 | US10081622, Compou...)
Affinity DataIC50: 411nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 484nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US9029356, 26 | US9255087, 26 | US10081622, Compou...)
Affinity DataIC50: 568nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158156(US9029356, 26 | US9255087, 26 | US10081622, Compou...)
Affinity DataIC50: 1.10E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 1.77E+3nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 2.35E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetAurora kinase B(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 3.23E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM158157(US9029356, 18 | US9255087, 18 | US10081622, Compou...)
Affinity DataIC50: 6.07E+3nMAssay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent