Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 6969
TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50: 2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36513(CID46912128 | KY170, 4 | US9056847, Azido-cyclophe...)
Affinity DataKi:  83nM IC50: 150nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  7.73E+3nM IC50: 1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent