Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 8184
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235917(US9365508, 392a (3,5-Cl2, 4-OBu))
Affinity DataIC50: 400nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235918(US9365508, 391a (3,5-Cl2, 4-OEt))
Affinity DataIC50: 3.00E+3nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363783(CHEMBL1945265 | US9365508, 361a (3-Br, 4 tBu))
Affinity DataIC50: 4.60E+3nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235915(US9365508, D3 (3-Cl, 4-OMe,)
Affinity DataIC50: 1.07E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235916(US9365508, 383a (3,5-Br2, 4-OMe))
Affinity DataIC50: 1.40E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363783(CHEMBL1945265 | US9365508, 361a (3-Br, 4 tBu))
Affinity DataIC50: 1.83E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363782(CHEMBL1945264 | US9365508, A6 (3-Br))
Affinity DataIC50: 2.12E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235917(US9365508, 392a (3,5-Cl2, 4-OBu))
Affinity DataIC50: 2.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235918(US9365508, 391a (3,5-Cl2, 4-OEt))
Affinity DataIC50: 2.93E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363784(CHEMBL1945266 | US9365508, 311d (3,4-Cl2))
Affinity DataIC50: 3.19E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
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TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235912(US9365508, 330a (3-Br, 4-Me))
Affinity DataIC50: 3.19E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 3.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363780(CHEMBL1945260 | US9365508, B5 (4-Br))
Affinity DataIC50: 3.95E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363782(CHEMBL1945264 | US9365508, A6 (3-Br))
Affinity DataIC50: 3.99E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235912(US9365508, 330a (3-Br, 4-Me))
Affinity DataIC50: 4.39E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235916(US9365508, 383a (3,5-Br2, 4-OMe))
Affinity DataIC50: 4.72E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235913(US9365508, C6 (3-CF3,)
Affinity DataIC50: 5.17E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235914(US9365508, D1 (3,4,5-F3))
Affinity DataIC50: 5.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363780(CHEMBL1945260 | US9365508, B5 (4-Br))
Affinity DataIC50: 6.21E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235915(US9365508, D3 (3-Cl, 4-OMe,)
Affinity DataIC50: 6.25E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50: 6.48E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363784(CHEMBL1945266 | US9365508, 311d (3,4-Cl2))
Affinity DataIC50: 7.09E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363785(CHEMBL1945670 | US9365508, A1 (2-Me))
Affinity DataIC50: 8.07E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235914(US9365508, D1 (3,4,5-F3))
Affinity DataIC50: 9.00E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM235913(US9365508, C6 (3-CF3,)
Affinity DataIC50: 9.00E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of St Andrews

US Patent
LigandPNGBDBM50363785(CHEMBL1945670 | US9365508, A1 (2-Me))
Affinity DataIC50: 9.00E+4nMAssay Description:All compounds were tested for inhibition of SIRT1 and SIRT2 using human recombinant enzymes available in the Fluor de Lys fluorescence-based assay ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent