Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 8247
LigandPNGBDBM238347(US9388165, 3)
Affinity DataIC50: 2.80nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 6.10nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238349(US9388165, 6)
Affinity DataIC50: 6.40nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238348(US9388165, 4)
Affinity DataIC50: 10.7nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238346(US9388165, 2)
Affinity DataIC50: 11nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238350(US9388165, 8)
Affinity DataIC50: 20.5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 61nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 66nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetSerine/threonine-protein kinase B-raf(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 87nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238351(US9388165, 11)
Affinity DataIC50: 94.8nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM238352(US9388165, 14)
Affinity DataIC50: 108nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 128nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 261nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 393nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetInsulin-like growth factor 1 receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
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Date in BDB:
7/17/2017
Entry Details
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TargetEpidermal growth factor receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent