Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 8423
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  110nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [N841I](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  16nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [K663Q](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  5.10nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  14nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [D835H](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  11nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  6.20nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  7.5nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetAurora kinase B(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  48nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 32nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 38nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 40nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 52nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 300nMAssay Description:Myc-tagged Aurora A was transfected in Hela cells using Lipofectamine LTX in 24 well plates, and 24 hours after transfection, cells were treated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 5.50E+3nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 9.50E+3nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 1.08E+4nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 1.10E+4nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 2.50E+4nMAssay Description:All hERG percentage inhibitions at 10 uM compound concentration were determined by Millipore in a high-throughput cell-based electrophysiology assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247370(US9447092, 3)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent