Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 174
LigandPNGBDBM201605(4-(6-chloro-2-((6-(pyrrolidin-1-yl)pyridin-2-yl)me...)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201626(4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Affinity DataIC50: 3.30nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
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LigandPNGBDBM202244(5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl...)
Affinity DataIC50: 4.5nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201625((e)-4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Affinity DataIC50: 6.30nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201613(6-chloro-n,n-dimethyl-2-((6-(pyrrolidin-1-yl)pyrid...)
Affinity DataIC50: 7nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202236((e)-5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-...)
Affinity DataIC50: 12nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202255((e)-5,8-dim ethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin...)
Affinity DataIC50: 18nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202195((e)-6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrroli...)
Affinity DataIC50: 27nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM201598(2-methyl-3-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Affinity DataIC50: 30nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202252((e)-5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-...)
Affinity DataIC50: 31nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201629(4-(2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)ethyl)qui...)
Affinity DataIC50: 46nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM201612(4-(2-((6-(pyrrolidin-1-yl)pyridin-2-yl)methoxy)qui...)
Affinity DataIC50: 50nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
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LigandPNGBDBM202279(2,3-dimethyl-5-((6-(pyrrolidin-1-yl)pyridin-2-yl)m...)
Affinity DataIC50: 69nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
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LigandPNGBDBM202231(6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrrolidin-...)
Affinity DataIC50: 81nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201599(2-methyl-3-[(e)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Affinity DataIC50: 90nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM201630(6-chloro-2-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Affinity DataIC50: 94nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202032(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)eth...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202253(5,7-dimethyl-2-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Affinity DataIC50: 110nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM201606(2-(2-(1-methyl-4-phenyl-1h-imidazol-2-yl)ethyl)-6-...)
Affinity DataIC50: 120nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM201603(2-methyl-3-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)-eth...)
Affinity DataIC50: 120nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202277(5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Affinity DataIC50: 140nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202081((1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-y...)
Affinity DataIC50: 150nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
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LigandPNGBDBM202243(2,3-dimethyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)m...)
Affinity DataIC50: 160nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
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LigandPNGBDBM202286(3-methyl-n-((6-(pyrrolidin-1-yl)pyridin-2-yl)methy...)
Affinity DataIC50: 200nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
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LigandPNGBDBM202028((e)-(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin...)
Affinity DataIC50: 220nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202232((e)-2-((6-(2-(6-chloro-4-(dimethylamino)quinazolin...)
Affinity DataIC50: 240nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202280(2-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Affinity DataIC50: 260nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201624(4-(1-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)me...)
Affinity DataIC50: 276nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202251(5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Affinity DataIC50: 300nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202287(2,3-dimethyl-5-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl...)
Affinity DataIC50: 300nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202029(5-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)eth...)
Affinity DataIC50: 400nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202030(6-chloro-5-methoxy-2-(2-(6-(pyrrolidin-1-yl)pyridi...)
Affinity DataIC50: 470nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202035(1-(6-(2-(4-(dimethylamino)quinazolin-2-yl)ethyl)py...)
Affinity DataIC50: 480nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201551((E)-2-[2-(4-Methyl-6-pyrrolidin-1-yl-pyrimidin-2-y...)
Affinity DataIC50: 530nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202278(2-ethyl-3-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-...)
Affinity DataIC50: 540nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202284(2-cyclopropyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Affinity DataIC50: 600nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
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Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201597(2,3,5-trimethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Affinity DataIC50: 600nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201593(4-methoxy-3,5-dimethyl-2-(2-(6-(pyrrolidin-1-yl)py...)
Affinity DataIC50: 610nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202254(2,3-dmethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Affinity DataIC50: 630nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202234((e)-6-chloro-2-(2-(6-(dimethylamino)pyridin-2-yl)v...)
Affinity DataIC50: 750nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202034(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-yl...)
Affinity DataIC50: 770nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201554((e)-4-methoxy-3,5-dimethyl-2-(2-(6-(pyrrolidin-1-y...)
Affinity DataIC50: 790nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202217((e)-1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-...)
Affinity DataIC50: 820nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202285(3-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Affinity DataIC50: 1.05E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201631(4-[2-(2h-pyrazol-3-yl)-6-(6-pyrrolidin-1-yl-pyridi...)
Affinity DataIC50: 1.08E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202146((1-(6-(2-(4-(dimethylamino)quinazolin-2-yl)ethyl)p...)
Affinity DataIC50: 1.63E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202027(4-(2-(pyridin-3-yl)-6-((6-(pyrrolidin-1-yl)pyridin...)
Affinity DataIC50: 1.63E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM202235(6-chloro-2-(2-(6-(dimethylamino)pyridin-2-yl)ethyl...)
Affinity DataIC50: 1.68E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201611(2-methyl-3-((6-(piperidin-1-yl)pyridin-2-yl)methox...)
Affinity DataIC50: 1.68E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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LigandPNGBDBM201594(2-(2-(1-methyl-4-phenyl-1h-imidazol-2-yl)ethyl)-6-...)
Affinity DataIC50: 1.84E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
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