Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 988
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095537(CHEMBL3590526 | US9598381, 1a (S enantiomer))
Affinity DataIC50: 23nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
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Date in BDB:
3/29/2019
Entry Details
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PDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095536(CHEMBL3590527 | US9598381, 1 (racemate))
Affinity DataIC50: 65nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095635(CHEMBL3590518 | US9598381, 2)
Affinity DataIC50: 138nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095635(CHEMBL3590518 | US9598381, 2)
Affinity DataIC50: 2.03E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301823( N-cyclohexyl-3-((2,3-dichlorophenethyl)amino)-N-(...)
Affinity DataIC50: 3.44E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095633(CHEMBL3590520 | US9598381, 3)
Affinity DataIC50: 3.74E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301822(N-cyclobutyl-3-((3,4-dichlorophenethyl)amino)-N-(2...)
Affinity DataIC50: 3.79E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095615(CHEMBL3590524 | US9598381, 13)
Affinity DataIC50: 7.42E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301815( N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(...)
Affinity DataIC50: 9.83E+3nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301797(N-cyclopentyl-3-((3,4-dichlorophenethyl)amino)-N-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095612(CHEMBL3590525 | US9598381, 5)
Affinity DataIC50: 1.12E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095625(CHEMBL3590523 | US9598381, 6)
Affinity DataIC50: 1.21E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301805(N-(2-((4-cyanobenzyl)amino)ethyl)-N-cyclohexyl-((3...)
Affinity DataIC50: 1.60E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301811(N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2...)
Affinity DataIC50: 3.28E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301812((S)-N-cyclohexyl-3-(phenethylamino)-N-(2-(2-((pyri...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM301813(N-cyclohexyl-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095634(CHEMBL3590519 | US9598381, 11)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetN-lysine methyltransferase SMYD2(Human)
Abbvie

US Patent
LigandPNGBDBM50095632(CHEMBL3590521 | US9598381, 14)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity of compounds having formula (I) to SMYD2 is indicia of their inhibition of the activity of this protein lysine methyltransferase. To...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent