Compile Data Set for Download or QSAR
Report error Found 387 Enz. Inhib. hit(s) with all data for entry = 1641
LigandPNGBDBM333882(tert-butyl (3S)-3-{[8-(2-tert- butyl-1,3-thiazol-5...)
Affinity DataIC50: 0.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333988((S)-1-(3-((9-ethyl-8-(6-methoxy- 5-methylpyridin-3...)
Affinity DataIC50: 0.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM333992((S)-1-(3-((9-ethyl-8-(1-ethyl-5- methyl-1H-pyrazol...)
Affinity DataIC50: 0.600nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333881(tert-butyl (3S)-3-{[9-ethyl-8-(6- methoxy-5-methyl...)
Affinity DataIC50: 0.700nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334016(US9730940, Compound 2-118 | US9730940, Compound 2-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334021(US9730940, Compound 2-123 | 9-ethyl-8-(2-methylpyr...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334026(6-({(3S)-1-[S- or R-(2,2- dimethylcyclopropyl)carb...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334032(9-ethyl-6-{[(3S)-1-{[(1S,2S)- or (1R,2R)-2- (fluor...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334043(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334079(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334081(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334083(5-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334085(8-(5-chloro-6-methoxypyridin- 3-yl)-6-{[(3S)-1- (c...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334099(N-[5-(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334108(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334110(6-({(3S)-1-[(3,3- difluorocyclobutyl)carbonyl]pyr-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334112(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334113(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-{[(3...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334114(6-({(3S)-1-[(3,3- difluorocyclobutyl)carbonyl]pyr-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334115(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-{[(3...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334116(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-({(3...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334119(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334122(9-ethyl-6-{[(3S)-1-(2- methylpropanoyl)pyrrolidin-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334126((S)-(3-((9-ethyl-8-(1-ethyl-5- methyl-1H-pyrazol-4...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334177((S)-(3-((9-ethyl-8-(6- (trifluoromethyl)pyridin-3-...)
Affinity DataIC50: 1nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334102(5-(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-...)
Affinity DataIC50: 1.10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM333923(6-({(3S)-1-[(2,2- dimethyltetrahydro-2H-pyran-4- y...)
Affinity DataIC50: 1.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334009(6-({(3S)-1-[(1R,2S,4S)- bicyclo[2.2.1]hept-2- ylca...)
Affinity DataIC50: 1.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334016(US9730940, Compound 2-118 | US9730940, Compound 2-...)
Affinity DataIC50: 1.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334029(9-ethyl-6-({(3S)-1-[(3- methylcyclobutyl)carbonyl]...)
Affinity DataIC50: 1.30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334128((R or S )-6-{[5- (cyclopropylcarbonyl)-5- azaspir...)
Affinity DataIC50: 1.30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334158(6-{[(3S)-1-(azetidin-1- ylcarbonyl)pyrrolidin-3-yl...)
Affinity DataIC50: 1.30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334030(US9730940, Compound 2-131 | (1S,2S)- or (1R,2R)-{[...)
Affinity DataIC50: 1.40nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334007(9-ethyl-6-({(3S)-1-[(2- methylcyclopropyl)carbonyl...)
Affinity DataIC50: 1.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334117(9-ethyl-8-(5-fluoro-6- methoxypyridin-3-yl)-6-({(3...)
Affinity DataIC50: 1.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333995((S)-1-(3-((8-(2-(tert- butyl)thiazol-5-yl)-9-methy...)
Affinity DataIC50: 1.60nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334111(9-ethyl-8-(6-methoxypyridin-3- yl)-6-{[(3S)-1-(tet...)
Affinity DataIC50: 1.60nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334209(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-pyr...)
Affinity DataIC50: 1.70nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334160(9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carb...)
Affinity DataIC50: 1.80nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334096(N-[2-methoxy-5-(9-methyl-6- {[(3S)-1-propanoylpyrr...)
Affinity DataIC50: 2nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333993((S)-1-(3-((8-(6-methoxy-5- methylpyridin-3-yl)-9-m...)
Affinity DataIC50: 2.10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334109(9-ethyl-8-(6-methoxypyridin-3- yl)-6-{[(3S)-1-(2- ...)
Affinity DataIC50: 2.10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333936(8-(1-ethyl-5-methyl-1H-pyrazol- 4-yl)-9-methyl-6-(...)
Affinity DataIC50: 2.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333994((S)-1-(3-((8-(2-(tert- butyl)thiazol-5-yl)-9-ethyl...)
Affinity DataIC50: 2.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334080(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]...)
Affinity DataIC50: 2.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334213(9-ethyl-6-{[(3S)-1-(3- fluorophenyl)pyrrolidin-3- ...)
Affinity DataIC50: 2.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334127(racemic-6-{[1- (cyclopropylcarbonyl)-4,4- dimethyl...)
Affinity DataIC50: 2.30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334098(9-methyl-6-{[(3S)-1- propanoylpyrrolidin-3-yl]oxy}...)
Affinity DataIC50: 2.40nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334100(5-(6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-...)
Affinity DataIC50: 2.40nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM334093(8-[4-methoxy-3- (trifluoromethyl)phenyl]-9- methyl...)
Affinity DataIC50: 2.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

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