Reaction Details  Report a problem with these data
Cell Reactant:
Estrogen-Related Receptor, alpha
Syringe Reactant:
BDBM22421
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2008-05-29
pH:
7.5000±n/a
Temperature:
298.1500±n/a (K)
ΔHobs :
-53.0860±n/a (kJ/mole)
Corrected for ΔHioniz:
no
ΔS° :
-0.0603±n/a (kJ/mole-K)
Citation
 Kallen, J; Lattmann, R; Beerli, R; Blechschmidt, A; Blommers, MJ; Geiser, M; Ottl, J; Schlaeppi, JM; Strauss, A; Fournier, B Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem 282:23231-9 (2007) [PubMed]  Article
Cell React
Source:
Recombinant ERR alpha ligand-binding domain was cloned and expressed in sf9 insect cells.
Purity:
The purification of the frozen Sf9 cell pellets was done by three-step chromatography. SDS-PAGE analysis revealed good and soluble expression of ERR apha LBD.
Name:
Steroid hormone receptor ERR1
Synonyms:
ERR-alpha | Estrogen receptor-like 1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | ERR1_HUMAN | ESRRA | NR3B1 | ERR1 | ESRL1 | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa)
Type:
PROTEIN
Mol. Mass.:
45508.08
Organism:
Human
Description:
ChEMBL_1499891
Residue:
423
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
  
Syringe React
Name:
BDBM22421
Synonyms:
(cyclohexylmethyl)[(1-phenyl-1H-indol-3-yl)methyl]amine | Indole compound 1b
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: