Reaction Details  Report a problem with these data
Cell Reactant:
XIAP-BIR3
Syringe Reactant:
BDBM26201
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2008-12-17
pH:
7.4000±n/a
Temperature:
298.1500±n/a (K)
Corrected for ΔHioniz:
no
Citation
 Huang, JW; Cywin, CL; Klunder, JM; Zhang, Z; Hoermann, M; Wu, B; Brickwood, JR; Cellitti, JF; David, E; Zhang, X; Grob, PM; Dahl, R; Schwartz, R; Shiau, CW; Pauletti, D; Welsh, K; Emdadi, A; Barringer, KJ; Stebbins, JL; Shih, CK; Reed, JC; Sorge, CL; Pellecchia, M; Erickson, DA; Joseph, DP; Hattox, SE Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors. J Med Chem 51:7111-8 (2008) [PubMed]  Article
Cell React
Source:
The protein was expressed in the Escherichia coli strain BL21(DE3).
Prep. Method:
The protein was purified using Ni2+ affinity chromatography.
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
baculovirus IAP repeat 3 (BIR3) domain of XIAP | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP_HUMAN | XIAP | API3 | BIRC4 | IAP3 | XIAP-BIR3 | E3 ubiquitin-protein ligase XIAP BIR-3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | BIR3 domain of X-linked inhibitor of apoptosis protein | E3 ubiquitin-protein ligase XIAP BIR3 | E3 ubiquitin-protein ligase (XIAP-BIR3)
Type:
Protein Binding Domain
Mol. Mass.:
13276.62
Organism:
Human
Description:
BIR3 of XIAP: RESIDUES 241-356.
Residue:
116
Sequence:
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Syringe React
Name:
BDBM26201
Synonyms:
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-4-methylhexanoic acid | AVPI
Type:
4-mer
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: