Reaction Details  Report a problem with these data
Cell Reactant:
Methylthioadenosine Phosphorylase (MTAP)
Syringe Reactant:
BDBM218799
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2017-03-22
pH:
7.4000±0.0000
Temperature:
293.1500±0.0000 (K)
ΔH° :
16.0000±0.2000 (kJ/mole)
Citation
 Firestone, RS; Cameron, SA; Karp, JM; Arcus, VL; Schramm, VL Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. ACS Chem Biol 12:464-473 (2017) [PubMed]  Article
Cell React
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase | MTA phosphorylase | MTAPase | MTAP_HUMAN | MTAP | MSAP | Methylthioadenosine Phosphorylase (MTAP)
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Human
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Syringe React
Name:
BDBM218799
Synonyms:
pCl-PhT-DADMe-ImmA
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1ncnc2c(C[NH+]3C[C@@H](O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12 |r|
Structure:
Search PDB for entries with ligand similarity: