Reaction Details  Report a problem with these data
Cell Reactant:
Histone deacetylase 1/3/5/8
Syringe Reactant:
BDBM19130
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2014-09-30
ΔG°:
-8.61±0 (kcal/mole)
Temperature:
298.1500±0.0000 (K)
ΔH° :
-8.85±0.12 (kJ/mole)
ΔS° :
-0±0 (kJ/mole-K)
Citation
 Singh, RK; Lall, N; Leedahl, TS; McGillivray, A; Mandal, T; Haldar, M; Mallik, S; Cook, G; Srivastava, DK Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. Biochemistry 52:8139-49 (2013) [PubMed]  Article 
Cell React
Name:
Histone deacetylase 8
Synonyms:
HD8 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | HDAC8_HUMAN | HDAC8 | HDACL1
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Human
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Syringe React
Name:
BDBM19130
Synonyms:
CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | TSA | Trichostatin A (TSA)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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