Reaction Details  Report a problem with these data
Cell Reactant:
Serine/threonine-protein kinase SRPK1
Syringe Reactant:
BDBM221074
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2017-04-06
ΔG°:
-9.92±n/a (kcal/mole)
pH:
7.5000±0.0000
Log10Kb:
8.3
Temperature:
303.1500±0.0000 (K)
ΔH° :
-5.98±0.19 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Citation
 Batson, J; Toop, HD; Redondo, C; Babaei-Jadidi, R; Chaikuad, A; Wearmouth, SF; Gibbons, B; Allen, C; Tallant, C; Zhang, J; Du, C; Hancox, JC; Hawtrey, T; Da Rocha, J; Griffith, R; Knapp, S; Bates, DO; Morris, JC Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol 12:825-832 (2017) [PubMed]  Article 
Cell React
Name:
SRSF protein kinase 1
Synonyms:
Serine/arginine-protein kinase 1 (SRPK1) | SRSF protein kinase 1 (SRPK1) | SRPK1_HUMAN | SRPK1 | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Human
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Syringe React
Name:
BDBM221074
Synonyms:
US9695160, 12 | SPHINX31 | US9796707, Compound 12
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: