Reaction Details  Report a problem with these data
Cell Reactant:
Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD)
Syringe Reactant:
BDBM223311
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2017-04-27
ΔG°:
-7.31±n/a (kcal/mole)
pH:
6.5000±0.0000
Temperature:
300.1500±0.0000 (K)
ΔH° :
-1.54±0.31 (kJ/mole)
ΔS° :
0.02±0 (kJ/mole-K)
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Cell React
Name:
Ephrin type-A receptor 3 [29-207]
Synonyms:
EPHA3_HUMAN | EPHA3 | ETK | ETK1 | HEK | TYRO4 | Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD)
Type:
Protein
Mol. Mass.:
20707.76
Organism:
Human
Description:
Human EphA3-LBD (29-207 aa)
Residue:
179
Sequence:
EVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVK
  
Syringe React
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r|
Structure:
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