| Assay Method Information | |
| | Fluorescence Polarization (FP) Assays |
| Description: | To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fluorescently tagged SMRT-based peptide for BCL6-BTB binding. The lower limit of this assay was 1 uM and was primarily used as a filter for compounds prior to our secondary assays. |
| Affinity data for this assay | |
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