| Assay Method Information | |
| | Binding Assay |
| Description: | Receptor Source: Human Cortex Radioligand: [3H]-Ketanserin (60-90 Ci/mmol) Control Compound: Ketanserin Incubation Conditions: The reactions were carried out in 50 mM TRIS-HCl (pH 7.6) at room temperature for 90 minutes. The reaction was terminated by rapid vacuum filtration onto glass fiber filters. Radioactivity trapped onto the filters was determined and compared to control values in order to ascertain any interactions of test compounds with the serotonin-5HT2A binding site (Literature Reference: Leysen, J. E. et al. Mol. Pharmacol. 1982, 21, 301-314; Martin, G. R. and Humphrey, P. P. A. Neuropharmacol. 1994, 33(3/4), 261-273.) |
| Affinity data for this assay | |
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