| Assay Method Information | |
| | Activity Assay |
| Description: | Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of intracellular and extracellular proteins. Thus inhibition of CatD may lead to unwanted pathophysiological conditions. CatD plays a role in the generation of biologically active peptides, the processing of exogenous antigens and to a smaller extent the beta-amyloid precursor protein. The development of a CatD activity assay is used to determine any potential cross reactivity for compounds selected from the β-secretase activity assay and to determine the selectivity to BACE1 inhibition. |
| Affinity data for this assay | |
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