Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) for PDB: 9AS1
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cells assessed as inhibition constant incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cells assessed as inhibition constant incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  65nMAssay Description:Compound was tested for the displacement of [125I]DOI from clone human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cells incubated for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataEC50:  181nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataIC50: 220nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cells incubated for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  416nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  416nMAssay Description:Affinity of Compound 1 and the reference compounds DMT and 5-MeO-DMT for the 5-HT2A receptor was determined in radioligand binding experiments with [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataEC50:  440nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataIC50: 500nMAssay Description:i. Prepared the assay buffer following the table below; Reagent Concentration Tris 50 mMCaCl2, 4 mMBSA, 0.1% (w/V) Adjust pH to 7.4 followed by 0.2 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataIC50: 2.00E+3nMAssay Description:i. Prepared the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 μM st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataKi:  2.32E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026868BDBM50026868(2-(1H-indol-3-yl)-N,N-dimethylethanamine | DMT | N...)
Affinity DataEC50: <1.00E+4nMAssay Description:The dye is diluted with assay buffer (20mM HEPES in 1x HBSS, PH7.4); Probenecid was added to the final concentration of 5 mM; Hi. Vortexed vigorously...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
WIPO WO2023019327
PDB3D3D Structure (crystal)