Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) for PDB: 9F6X
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 44nMAssay Description:Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ALK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ALK5 assessed as inhibition of immobilized Smad3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 47nMAssay Description:Inhibition of GST-tagged ALK5 kinase domain (unknown origin) using GST-tagged SMAD3 as substrate in presence of [33P] gammaATP by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 47nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 54nMAssay Description:Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 54.4nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells using casein as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivin receptor type-1B(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 70nMAssay Description:Inhibition of ALK4 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Mouse)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 77nMAssay Description:Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivin receptor type-1B(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 129nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 169nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 594nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 594nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 594nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298220BDBM50298220(2-(5-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Affinity DataIC50: 668nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)