Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 9LL7
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataIC50: 0.460nMAssay Description:Displacement of [125I]DOI from 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataEC50:  2.85nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2A receptor expressed in HEK cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]ketanserin from rat prefrontal cortex 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataKi:  10nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataEC50:  17.8nMAssay Description:Agonist activity at 5HT2A receptor in rat A7r5 cells assessed as intracellular calcium mobilization relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataEC50:  20nMAssay Description:Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Alcon Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133231BDBM50133231((R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylam...)
Affinity DataEC50:  27.7nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)