Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 9OOQ
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataEC50:  91nMAssay Description:Agonist activity at rat GluN1/GluN2D NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20180BDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20180BDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate NMDA receptor; Grin1/Grin2c(Rat)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataEC50:  210nMAssay Description:Agonist activity at rat GluN1/GluN2C NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rat)
University of Copenhagen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut De Recherches Servier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20180BDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20180BDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  530nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20180BDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  650nMAssay Description:Positive allosteric modulation of recombinant rat GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutama...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
Sage Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataEC50:  990nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut De Recherches Servier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18133BDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)