Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 9PWG
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  3.80E+3nMAssay Description:In the first set of data, the potency and in vitro effects of test compounds were evaluated on cloned hTRPM8 channel (encoded by the human TRPM8 gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  1.01E+4nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataKd:  1.44E+4nMAssay Description:Binding affinity to human TRPM8 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  2.90E+4nMAssay Description:Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  6.00E+4nMAssay Description:Agonist activity at TRPM8 (unknown origin) by fluorometric imaging plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  7.50E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataIC50: 9.20E+4nMAssay Description:Displacement of [3H]menthol from human TRPM8 expressed in HEK293 cell membranes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50318482BDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  2.00E+5nMAssay Description:Agonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)