Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) for PDB: 9SH5
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 15nMAssay Description:Inhibition of TNAP (unknown origin) using PPi as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 125nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 143nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 150nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 190nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 194nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 201nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 230nMAssay Description:Inhibition of TNAP right after mixing with enzyme (EI 0:0) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 237nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 240nMAssay Description:Inhibition of TNAP after 1 hr incubation with enzyme post-dilution (EI 1:0) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 270nMAssay Description:Inhibition of TNAP after 1 hr pre-incubation with enzyme (EI 1:1) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataKi:  340nMAssay Description:Inhibition of TNAP using CDP-star as substrate by non-competitive Lineweaver-Burke plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 530nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataKi:  590nMAssay Description:Inhibition of TNAP using DEA as substrate by non-competitive Lineweaver-Burke plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 1.29E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299523BDBM50299523(cid_2931238 | CHEMBL567850 | 2,5-Dimethoxy-N-(quin...)
Affinity DataIC50: 6.14E+3nMAssay Description:Inhibition of TNAP (unknown origin) in whole blood using pNPP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)