Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 9V6T
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (un...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataIC50: 112nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  611nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  655nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  2.92E+3nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  2.21E+4nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  4.86E+4nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled receptor 84(Human)
Galapagos

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548385BDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataEC50:  9.24E+4nMAssay Description:Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)