Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 9W8B
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  4nMAssay Description:Inhibition constant against [3H]nicotine binding to vesicular monoamine transporter-2 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataIC50: 381nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  470nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  1.84E+3nMAssay Description:Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  2.76E+3nMAssay Description:Inhibition of 5 nM [3H]DTBZ binding to Vesicular Monoamine Transporter (VAMT2) of rat vesicle membranes More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  2.76E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  2.76E+3nMAssay Description:Inhibition constant against [3H]dihydrotetrabenazine binding to vesicular monoamine transporter-2 of rat synaptic vesicle membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  2.76E+3nMAssay Description:Displacement of [3H]dihydrotetrabenazine from vesicular monoamine transporter-2 in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  6.26E+3nMAssay Description:Inhibition constant against [3H]methyllycaconitine binding to vesicular monoamine transporter-2 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50080818BDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)