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TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110121(AcAsp-Glu-Dif-Glu-Cha-Fab | 3-[2-(2-{2-[2-(2-Acety...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110121(AcAsp-Glu-Dif-Glu-Cha-Fab | 3-[2-(2-{2-[2-(2-Acety...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461540(CHEMBL4226033)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50142916(CHEMBL297884 | BILN 2061 | (1S,4R,6S,14S,18R)-14-C...)
Affinity DataKi:  0.0890nMAssay Description:Inhibition of HCV genotype-1a NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461545(CHEMBL4226876)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50495950(Danoprevir | R-05190591 | R05190591 | RO-5190591 |...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573903(CHEMBL4852970)
Affinity DataKi:  0.200nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452540(CHEMBL4215698)
Affinity DataEC50:  0.200nMAssay Description:Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50458698(CHEMBL4203709)
Affinity DataKi:  0.200nMAssay Description:Inhibition of wild type HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) using Ac-DE-Dap(QXL 520)-EE-Abu-psi-[COO]AS-C(5-FAMsp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461549(CHEMBL4225009)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461552(CHEMBL4228791)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461537(CHEMBL4228440)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461556(CHEMBL4225149)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461547(CHEMBL4225051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452540(CHEMBL4215698)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50142916(CHEMBL297884 | BILN 2061 | (1S,4R,6S,14S,18R)-14-C...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HCV 1a NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452517(CHEMBL4202696)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573887(CHEMBL4879085)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461555(CHEMBL4225768)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461554(CHEMBL4225514)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461539(CHEMBL4229110)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461551(CHEMBL4229052)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HCV GT-3a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573886(CHEMBL4848452)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452517(CHEMBL4202696)
Affinity DataEC50:  0.5nMAssay Description:Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573919(CHEMBL4854503)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452535(CHEMBL4205832)
Affinity DataEC50:  0.600nMAssay Description:Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573914(CHEMBL4875061)
Affinity DataKi:  0.700nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573915(CHEMBL4864092)
Affinity DataKi:  0.700nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461542(CHEMBL4224705)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50158804(AcAsp-D-Gla-Leu-Ile-Cha-Cys | CHEMBL179084)
Affinity DataKi:  0.75nMAssay Description:Inhibitory constant against hepatitis C virus NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50366760(CHEMBL2369589)
Affinity DataKi:  0.75nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50458698(CHEMBL4203709)
Affinity DataKi:  0.800nMAssay Description:Inhibition of HCV genotype 1a NS3/4A protease R155K mutant expressed in Escherichia coli BL21(DE3) using Ac-DE-Dap(QXL 520)-EE-Abu-psi-[COO]AS-C(5-FA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461541(CHEMBL4225301)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461564(CHEMBL4228533)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573881(CHEMBL4848772)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573902(CHEMBL4860811)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573884(CHEMBL4863541)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50452534(CHEMBL4210795)
Affinity DataEC50:  1nMAssay Description:Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50287622(CHEMBL4160876)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50198324(CHEMBL3933212)
Affinity DataEC50:  1nMAssay Description:Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50287594(Asunaprevir | BMS 650032 | BMS-650032)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50287594(Asunaprevir | BMS 650032 | BMS-650032)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573880(CHEMBL4847539)
Affinity DataKi:  1.10nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50573883(CHEMBL4863232)
Affinity DataKi:  1.10nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50461562(CHEMBL4227396)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
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