Compile Data Set for Download or QSAR
Report error Found 18658 for UniProtKB: O00329
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652796(Sonolisib | Px-866 | PX-866)
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataKi:  0.0126nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataKi:  0.0158nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of P13Kdelta (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity to p110 delta (unknown origin) assessed as inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataKi:  0.0316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM172655(US9090628, 316 | US9090628, 315)
Affinity DataIC50: 0.0350nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

LigandPNGBDBM172706(US9090628, 366)
Affinity DataIC50: 0.0350nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

LigandPNGBDBM50197062(Pilaralisib | SAR-245408 | XL-147)
Affinity DataIC50: 0.0360nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50512885(CHEMBL4441003)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PI3Kdelta (unknown origin) preincubated for 30 mins followed by insulin stimulation for 5 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50652795(CHEMBL3349370)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM464391(US10792283, Compound 1)
Affinity DataIC50: 0.0430nMAssay Description:Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

LigandPNGBDBM571544(US11446301, Compound 1)
Affinity DataIC50: 0.0430nMAssay Description:The TR-FRET assay can monitor formation of the product 3,4,5-inositol triphosphate molecule (PIP3) as it competed with fluorescently labeled PIP3 for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandPNGBDBM172707(US9090628, 367)
Affinity DataIC50: 0.0480nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataKi:  0.0631nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataKi:  0.0790nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50573170(CHEMBL4855234)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human full length P13Kdelta expressed in Sf9 cells assessed as reduction in ATP-dependent phosphorylation by chromatography...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50579634(CHEMBL4860369)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human PI3K p110delta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandPNGBDBM464392(US10792283, Compound 2)
Affinity DataIC50: 0.0860nMAssay Description:Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

LigandPNGBDBM571545(US11446301, Compound 2)
Affinity DataIC50: 0.0860nMAssay Description:The TR-FRET assay can monitor formation of the product 3,4,5-inositol triphosphate molecule (PIP3) as it competed with fluorescently labeled PIP3 for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandPNGBDBM50576618(CHEMBL4868117)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of recombinant human full length His-tagged p110delta/p85alpha expressed in baculovirus expression system measured after 60 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50064300(CHEMBL3403664)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50512880(CHEMBL4468379)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta in human SUDHL6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI-3K delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50168293(CHEMBL3805430)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50168293(CHEMBL3805430)
Affinity DataIC50: 0.100nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50512862(CHEMBL4541570)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50168297(CHEMBL3805760 | US9765060, Compound 96)
Affinity DataIC50: 0.100nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent

LigandPNGBDBM50168290(CHEMBL3805572)
Affinity DataIC50: 0.100nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed
LigandPNGBDBM172459(US9090628, 102 | US9090628, 104 | US9090628, 103 |...)
Affinity DataIC50: 0.102nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

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