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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528241(CHEMBL334285)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528240(CHEMBL151546)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448940(N-(5-(4-Ethylpiperazin-1-yl)pyridin-2-yl)-5-fluoro...)
Affinity DataIC50: 0.0700nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50528239(CHEMBL148580)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448950(N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50: 0.0800nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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LigandPNGBDBM462173((Scheme A-13): (3R,4R)-4-({5-chloro-4-[1-(1,1-difl...)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462174((Scheme A-14): Preparation of (3R,4R)-4-[(5-chloro...)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556330(US11351170, Example 9 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 0.100nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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LigandPNGBDBM462081(US10766884, Example A02 | US11220494, Example A02)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462080(US10766884, Example A01 | US11220494, Example A01)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462208(US10766884, Example F26 | US11220494, Example F26)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462177(US10766884, Example B01 | US11220494, Example B01)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462177(US10766884, Example B01 | US11220494, Example B01)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462208(US10766884, Example F26 | US11220494, Example F26)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462100(US10766884, Example A17 | US11220494, Example A17)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462092(US10766884, Example A09)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM50593904(CHEMBL5198209)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM462229(US10766884, Example E01)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462197(US10766884, Example F15 | US11220494, Example F15)
Affinity DataKi: <0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM533351(US11220494, Example A09)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462100(US10766884, Example A17 | US11220494, Example A17)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462130(US10766884, Example A47 | US10766884, Example A48 ...)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462162(US10766884, Example A78 | US11220494, Example A78)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462162(US10766884, Example A78 | US11220494, Example A78)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462130(US10766884, Example A47 | US10766884, Example A48 ...)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462080(US10766884, Example A01 | US11220494, Example A01)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462081(US10766884, Example A02 | US11220494, Example A02)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462174((Scheme A-14): Preparation of (3R,4R)-4-[(5-chloro...)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462173((Scheme A-13): (3R,4R)-4-({5-chloro-4-[1-(1,1-difl...)
Affinity DataKi:  0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462108(US10766884, Example A25)
Affinity DataKi: <0.100nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462181(US10766884, Example D01 | US11220494, Example E01)
Affinity DataKi:  0.100nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556335(US11351170, Example 12 | 5-fluoro-4-(5-fluoro-1,1-...)
Affinity DataIC50: 0.110nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556334(US11351170, Example 11 | 3-(4-((6-(5-fluoro-4-(5-f...)
Affinity DataIC50: 0.110nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448926(1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihyd...)
Affinity DataIC50: 0.120nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of CDK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM132266(US8841312, 8)
Affinity DataIC50: 0.130nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50455050(CHEMBL4208172 | US10696678, Example 18 | US1135117...)
Affinity DataIC50: 0.140nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556329(US11351170, Example 8 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 0.160nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM467012((+)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of non-phosphorylated CDK4/Cyclin D3 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.160nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370119(US10233188, Example 8)
Affinity DataKi:  0.160nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.160nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM448950(N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluor...)
Affinity DataIC50: 0.170nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM556328(US11351170, Example 7 | (S)—N-(5-(3-(dimethyl...)
Affinity DataIC50: 0.180nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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LigandPNGBDBM462172((Scheme A-12): Preparation of (3R,4R)-4-({5-chloro...)
Affinity DataKi:  0.200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462119(US10766884, Example A36 | US11220494, Example A36)
Affinity DataKi:  0.200nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462109(US10766884, Example A26 | US11220494, Example A26)
Affinity DataKi:  0.200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462175((Scheme A-15): Preparation of 1,5-anhydro-3-({5-ch...)
Affinity DataKi:  0.200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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LigandPNGBDBM462145(US10766884, Example A61 | US11220494, Example A61)
Affinity DataKi:  0.200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
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TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM525562(US11174252, Compound 1)
Affinity DataIC50: 0.200nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
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