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TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  299nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK8 co-expressed with N-terminal GST-tagged CyclinC expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  259nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK19 co-expressed with N-terminal GST-tagged CyclinC expressed in baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  148nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK8 co-expressed with N-terminal GST-tagged CyclinC expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  125nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK19 co-expressed with N-terminal GST-tagged CyclinC expressed in baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  310nMAssay Description:Inhibition of CDK8/CyclinC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  310nMAssay Description:Inhibition of CDK8/CyclinC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50540076(CHEMBL4649097)
Affinity DataKd:  10nMAssay Description:Binding affinity to CDK8/cyclin C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  2nMAssay Description:Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  3nMAssay Description:Binding affinity to recombinant human CDK19/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to recombinant human CDK19/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350239(US10208056, Compound 66)
Affinity DataIC50: 0.191nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248627(CHEMBL4078454)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350249(US10208056, Compound 76)
Affinity DataIC50: 0.262nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350256(US10208056, Compound 83)
Affinity DataIC50: 0.278nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350253(US10208056, Compound 80)
Affinity DataIC50: 0.314nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248633(CHEMBL4083552)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248645(CHEMBL4061525)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632902(CHEMBL5435821)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248623(CHEMBL4096487)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632896(CHEMBL5434183)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632908(CHEMBL5409410)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350262(US10208056, Compound 89)
Affinity DataIC50: 0.407nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248614(CHEMBL4066819)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350240(US10208056, Compound 67)
Affinity DataIC50: 0.466nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248635(CHEMBL4070408)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350259(US10208056, Compound 86)
Affinity DataIC50: 0.480nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632903(CHEMBL5405004)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632905(CHEMBL5414359)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241875(CHEMBL4091527)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248633(CHEMBL4083552)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248656(CHEMBL4086487)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248656(CHEMBL4086487)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248645(CHEMBL4061525)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248640(CHEMBL4074204)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632901(CHEMBL5416117)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248690(CHEMBL4082469)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50265275(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189434(CHEMBL3828221)
Affinity DataIC50: 0.710nMAssay Description:Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632907(CHEMBL5402477)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350253(US10208056, Compound 80)
Affinity DataIC50: 0.770nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248635(CHEMBL4070408)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350249(US10208056, Compound 76)
Affinity DataIC50: 0.827nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632904(CHEMBL5411825)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM640341(8-Amino-N-(cyclopropylmethyl)-5-(4- (1-(2-(dimethy...)
Affinity DataIC50: 0.880nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
Go to US Patent

TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632915(CHEMBL5440319)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50: 0.900nMAssay Description:Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) measured after 1 hr by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632898(CHEMBL5416758)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
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