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Report error Found 1125 for UniProtKB: P34975
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021327(CHEMBL359154 | 3-(1,3-Dimethyl-piperidin-3-yl)-phe...)
Affinity DataKd:  625nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021324(3-(1-Cyclopropylmethyl-3-methyl-piperidin-3-yl)-ph...)
Affinity DataKd:  83nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021323(CHEMBL151270 | 3-(1-Allyl-3-methyl-piperidin-3-yl)...)
Affinity DataKd:  137nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  625nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50452273(Dihydromorphine)
Affinity DataKd:  830nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50381677(U-69593 | CHEMBL1256748)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at rat kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026762(CHEMBL3331510)
Affinity DataEC50:  480nMAssay Description:Agonist activity at rat kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026763(CHEMBL3331511)
Affinity DataEC50:  205nMAssay Description:Agonist activity at rat kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50079413(Opioid Peptide [d-Ala(8)]Dynorphin derivative | Ty...)
Affinity DataEC50:  515nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133052(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  46.9nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133054(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  3.56nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133056(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  573nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133055(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  36.5nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133050(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  72.4nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133051(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133053(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  1.24nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50133049(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataEC50:  29.4nMAssay Description:Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138765(cyclo[D-Trp3]Dyn A-(1-11)NH2 | CHEMBL405307)
Affinity DataEC50:  12nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138771(cyclo[Pro3]Dyn A-(1-11)NH2 | CHEMBL438044)
Affinity DataEC50:  153nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138766(cyclo[D-Ala3]Dyn A-(1-11)NH2 | CHEMBL439272)
Affinity DataEC50:  0.540nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138777(cyclo[Trp3]Dyn A-(1-11)NH2 | CHEMBL414904)
Affinity DataEC50:  4.19nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138770(cyclo[D-Asp2,Dap5]Dyn A-(1-11)NH2 | CHEMBL411282)
Affinity DataEC50:  0.390nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50138780(cyclo[Ala3]Dyn A-(1-11)NH2 | CHEMBL261992)
Affinity DataEC50:  0.650nMAssay Description:Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21130(U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...)
Affinity DataKd:  1nMAssay Description:Binding affinity to rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50297343((5S,8S,13S,Z)-13-((S)-2-amino-3-(4-hydroxyphenyl)p...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50297345((5S,8S,13R,Z)-13-((S)-2-amino-3-(4-hydroxyphenyl)p...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50297347(CHEMBL564095 | (2S,5S,8S,13S,Z)-13-((S)-2-(2-(2-((...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50297347(CHEMBL564095 | (2S,5S,8S,13S,Z)-13-((S)-2-(2-(2-((...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50010704(Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Ly...)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at rat cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKd:  4.5nMAssay Description:Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021328(CHEMBL149414 | 3-Cyclopropylmethyl-11-ethyl-8-hydr...)
Affinity DataKd:  0.300nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKd:  1nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021322(3-(3-Methyl-1-phenethyl-piperidin-3-yl)-phenol | C...)
Affinity DataKd:  179nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  8nMAssay Description:Effective concentration to inhibit D216,ND217N,E218Q KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0500nMAssay Description:Dissociation constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  6nMAssay Description:Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0290nMAssay Description:Dissociation constant against wild type EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM224024(Dynorphin A (1-13) | YGGFLRRXRPKLK | BDBM50241435)
Affinity DataEC50:  18nMAssay Description:Effective concentration to inhibit wild type KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0380nMAssay Description:Dissociation constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0500nMAssay Description:Dissociation constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50225931(CHEMBL3038191)
Affinity DataEC50:  180nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataEC50:  3nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225932(CHEMBL2310918)
Affinity DataEC50:  90nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225933(CHEMBL2310921)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225934(CHEMBL2310922)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225935(CHEMBL2310915)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225936(CHEMBL3038190)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225937(CHEMBL3038189)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225938(CHEMBL2310919)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225939(CHEMBL3038192)
Affinity DataEC50:  130nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
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