Compile Data Set for Download or QSAR
Report error Found 23 of affinity data for UniProtKB/TrEMBL: Q01717
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataEC50:  0.5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataEC50:  290nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataKi:  3nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  20nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  42nMAssay Description:Inhibition of [3H][3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataKi:  320nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity was measured on TRH receptor using [3H]- MeTRH as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity was measured on TRH receptor using [3H]- MeTRH as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50156183(3-carbamoyl-1-{6-(2-carbamoyl-pyrrolidin-1-yl)-6-o...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H][3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50156182(3-carbamoyl-1-{5-(2-carbamoyl-pyrrolidin-1-yl)-5-o...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H][3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50156181(3-carbamoyl-1-{3-(2-carbamoyl-pyrrolidin-1-yl)-3-o...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H][3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50156179(3-carbamoyl-1-{4-(2-carbamoyl-pyrrolidin-1-yl)-4-o...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H][3-Me-His2]-TRH binding to thyrotropin releasing hormone receptor of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed