Compile Data Set for Download or QSAR
Report error Found 30 of affinity data for UniProtKB/TrEMBL: Q15465
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311528((S,E)-N-(4-chlorobenzyl)-2-(5,13-dioxo-1-oxa-4-aza...)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50612865(CHEMBL5276737)
Affinity DataKd:  170nMAssay Description:Binding affinity to Shh (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50590850(CHEMBL5185285)
Affinity DataKd:  550nMAssay Description:Binding affinity to SHH (unknown origin) assessed as dissociation constant by calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to N-terminal sonic hedgehog (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to SHHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to N-terminal Shh by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50323698(2-((3S,6S,12S,E)-12-amino-3-methyl-5,13-dioxo-1-ox...)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to N-terminal Shh by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311530((R,E)-N-(4-chlorobenzyl)-2-(5,13-dioxo-1-oxa-4-aza...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311529((R,E)-N-(4-chlorobenzyl)-2-(5,14-dioxo-1-oxa-4-aza...)
Affinity DataKd:  3.82E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50017346(CHEMBL3288258)
Affinity DataKd:  2.70E+4nMAssay Description:Binding affinity to human recombinant Shh by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311527((S,E)-N-(4-chlorobenzyl)-2-(5,12-dioxo-1-oxa-4-aza...)
Affinity DataKd:  2.38E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311526((S,E)-N-(4-chlorobenzyl)-2-(5,14-dioxo-1-oxa-4-aza...)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311524(N-(4-chlorobenzyl)-2-((2S,6R,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  8.70E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50017347(CHEMBL3288259)
Affinity DataKd:  1.22E+5nMAssay Description:Binding affinity to human recombinant Shh by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50017345(CHEMBL3288260)
Affinity DataKd:  2.30E+4nMAssay Description:Binding affinity to human recombinant Shh by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311517((R,E)-N-(4-chlorobenzyl)-2-(5,12-dioxo-1-oxa-4-aza...)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311518(N-(4-chlorobenzyl)-2-((2R,6R,E)-5,13-dioxo-2-pheny...)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311519(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,13-dioxo-2-pheny...)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311520(N-(4-chlorobenzyl)-2-((2R,6R,E)-5,12-dioxo-2-pheny...)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311521(N-(4-chlorobenzyl)-2-((2S,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  570nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311522(N-(4-chlorobenzyl)-2-((2S,6S,E)-5,13-dioxo-2-pheny...)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311523(N-(4-chlorobenzyl)-2-((2S,6R,E)-5,14-dioxo-2-pheny...)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311525(N-(4-chlorobenzyl)-2-((2S,6R,E)-5,13-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 100nMAssay Description:Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50170645(5'-hydroxy-2',3,6,15'-tetramethyl-(1'S,2'R,2'R,3R,...)
Affinity DataIC50: 500nMAssay Description:Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50: 600nMAssay Description:Inhibition of human Shh-induced mouse C3H10T1/2 cell differentiation after 48 hrs by alkaline phosphatase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Shh-induced mouse C3H10T1/2 cell differentiation after 48 hrs by alkaline phosphatase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed