Compile Data Set for Download or QSAR
Report error Found 22 of affinity data for UniProtKB/TrEMBL: Q93088
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataKd:  280nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli by intrinsic tryptophan fluorescence studiesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268080((S)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataKd:  83nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268080((S)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268079((RS)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylp...)
Affinity DataIC50: 84nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50: 93nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189914((R,S)-2-amino-4-(2-carboxymethylsulfanyl-ethylsulf...)
Affinity DataIC50: 96nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50: 138nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268078((RS,RS)-5-(3-Amino-3-carboxypropylthio)-3-methylpe...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189912((R,S)-6-(3-amino-3-carboxy-propylsulfanyl)-hexanoi...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268032((RS)-5-(3-Amino-3-carboxypropylselanyl)pentanoic A...)
Affinity DataIC50: 649nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268081((R)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataIC50: 701nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436836(CHEMBL2403304)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268055((RS)-2-Amino-4-{2-[(carboxymethyl)(methyl)amino]et...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268031((RS)-2-Amino-4-[(2-carboxyethylthio)methylthio]but...)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189915((R,S)-5-(3-amino-3-carboxy-propylsulfinyl)-pentano...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436835(CHEMBL2403303)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189916((R,S)-2-amino-4-(4-phosphono-butylsulfanyl)-butyri...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189913((R,S)-4-(3-amino-3-carboxy-propylsulfanyl)-benzoic...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50395382(CHEMBL2164724)
Affinity DataIC50: 7.66E+4nMAssay Description:Inhibition of recombinant human BHMT expressed in Escherichia coli BL31(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436834(CHEMBL2403302)
Affinity DataIC50: 2.19E+5nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBetaine--homocysteine S-methyltransferase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli using variable levels of betaine substrate by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)