Compile Data Set for Download or QSAR
Report error Found 3521 for UniProtKB: Q96SW2
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586185(CHEMBL5090416)
Affinity DataIC50: 0.0200nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586179(CHEMBL4744617)
Affinity DataIC50: 0.310nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586184(CHEMBL5078429)
Affinity DataIC50: 0.450nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50630767(CHEMBL5279477)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50643720(CHEMBL5574408)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594639(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627056(US11787802, Example 62 | 5-(4-Acetylpiperazin-1-yl...)
Affinity DataKd: <1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631105(US11802131, Example 32 | (4S)-N-[(3S)-2,6-Dioxopip...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594700(8-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-1,3,8-triaz...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594643((+)-2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594705(8-(4-Nitrophenyl)-1,3,8-triazaspiro[4.5]decane-2,4...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594640(2-(Thiazolo[4,5-b]pyridin-2-yl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631102(US11802131, Example 29 | (S)-N-(2,6-Dioxopiperidin...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627126(US11787802, Example 132 | 3-Methoxy-N-(2-oxo-2,3-d...)
Affinity DataKd: <1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627064(US11787802, Example 70 | 2-(4-Aminophenyl)-N-(2-ox...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594645(2-(Benzo[d]thiazol-2-yl)-2,7-diazaspiro[4.5]decane...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594708(8-Benzoyl-2,8-diazaspiro[4.5]decane-1,3-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631110(US11802131, Example 37 | N-[(3S)-2,6-Dioxo-3-piper...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627038(US11787802, Example 44 | 1-Methyl-5-phenyl-3H-imid...)
Affinity DataKd: <1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631088(US11802131, Example 15 | (1S)-N-(2,6-Dioxopiperidi...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627100(US11787802, Example 106 | 2-(4-(N-Methylsulfamoyl)...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631095(US11802131, Example 22 | (N-((R)-2,6-Dioxopiperidi...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627049(US11787802, Example 55 | 6-(Indoline-1-carbonyl)-1...)
Affinity DataKd: <1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594699(8-(Benzofuran-3-carbonyl)-1,3,8-triazaspiro[4.5]de...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631092(US11802131, Example 19 | N-((S)-2,6-Dioxopiperidin...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631094(US11802131, Example 21 | (S)-N-(2,6-Dioxopiperidin...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693802(3-(5-(((1S,2S)-2-(3-((cis)-4- isopropoxycyclohexyl...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM562168(US11401256, Example 60 | 6-(3,4-Dihydro-2H-quinoli...)
Affinity DataKd:  1nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627024(US11787802, Example 30 | 2-Isopropyl-N-methyl-2...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627088(US11787802, Example 94 | 1-Benzyl-3-(2-oxo-2,3-dih...)
Affinity DataKd: <1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594669(2-Benzoyl-2,7-diazaspiro[4.5]decane-6,8-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693805(3-(5-(((1S,2S)-2-(3-(4- ethoxycyclohexyl)azetidin-...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594668(2-(1-Acetylindoline-4-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627018(US11787802, Example 24 | 5-(Indoline-1-carbonyl)-1...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627021(US11787802, Example 27 | 1-Methyl-2-oxo-N-phenyl-3...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594672(2-(5-Aminopyridin-2-yl-2,7-diazaspiro[4.5]decane-6...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594678(2-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-2,7-diazasp...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM693807(3-(5-(((1S,2S)-2-(3-(4- (difluoromethoxy)cyclohexy...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM627006(US11787802, Example 12 | 5-(2-(Quinolin-4-yl)-1H-i...)
Affinity DataKd:  1nMAssay Description:1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content2) Titration measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631120(US11802131, Example 47 | (S)-N-(2,6-Dioxopiperidin...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631121(US11802131, Example 48 | (R)-N-(2,6-Dioxopiperidin...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631122(US11802131, Example 49 | (R)-N-(2,6-Dioxopiperidin...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631116(US11802131, Example 43 | (4S)-N-[(3R)-2,6-Dioxopip...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594663(2-(5-Nitropyridin-2-yl)-2,7-diazaspiro[4.5]decane-...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631127(US11802131, Example 54 | US11802131, Example 56 | ...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594662(2-(Benzo[d]thiazole-5-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631128(US11802131, Example 55 | (R)-N-(2,6-Dioxopiperidin...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594666(2-(5-Nitro-1H-benzo[d]imidazol-2-yl)-2,7-diazaspir...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM594665(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50586180(CHEMBL5082689)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
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