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TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303763((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  3.30E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303764((S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  3.50E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303767((2S,5S,8S,11S,14S,17S,20S,23S)-23-(2-((S)-2-((S)-2...)
Affinity DataKd:  8.50E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303768(CHEMBL578183)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (55...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303763((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  3.30E+4nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303764((S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  3.50E+4nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50277936((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM102348(US8536181, A41 | US9278930, A41 | US10562854, No. ...)
Affinity DataEC50:  1.70E+4nMAssay Description:Inhibition of PHD2 in HEK293 cells assessed as VEGF release by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50424584(CHEMBL2312530)
Affinity DataKd:  100nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26122(FUMARIC ACID | Fumarate | (2E)-but-2-enedioic acid...)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataKd:  420nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataKd:  80nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataKd:  2.00E+3nMAssay Description:Displacement of [13C]-2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50424584(CHEMBL2312530)
Affinity DataKd:  110nMAssay Description:Displacement of [13C]-2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50303766(2-oxopentanedioic acid | 2-oxoglutaric acid | alph...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286068(CHEMBL4171201)
Affinity DataEC50:  5.80E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286069(CHEMBL4174815)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286072(CHEMBL4164403)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286224(CHEMBL4162891)
Affinity DataEC50:  1.70E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286228(CHEMBL4174643)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286229(CHEMBL4167612)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286233(CHEMBL4175892)
Affinity DataEC50:  5.80E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataEC50:  1.90E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataEC50:  7.90E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286246(CHEMBL4159695)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286247(CHEMBL4164159)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286230(CHEMBL4171371)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286248(CHEMBL4168030)
Affinity DataEC50:  4.20E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286251(CHEMBL4167844)
Affinity DataEC50:  9.30E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286249(CHEMBL4159929)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286231(CHEMBL4175056)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286070(CHEMBL4166512)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286232(CHEMBL4173606)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286250(CHEMBL4159751)
Affinity DataEC50:  5.80E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286227(CHEMBL4160770)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50286263(CHEMBL4167657)
Affinity DataEC50:  1.30E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
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