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BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 728K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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29 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal EBI
Rigel Pharmaceuticals
Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.EBI
Rigel Pharmaceuticals
Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate.EBI
Rigel Pharmaceuticals
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.EBI
Rigel Pharmaceuticals
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.EBI
Rigel Pharmaceuticals
Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors.EBI
Rigel Pharmaceuticals
Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy.EBI
Rigel Pharmaceuticals
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.EBI
Rigel Pharmaceuticals
GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOFBDB
Deciphera Pharmaceuticals
Substituted piperazines as BTK inhibitorsBDB
Hutchison Medipharma
Fluoroalkyl-oxadiazoles and uses thereofBDB
Tenaya Therapeutics
Heterocyclic compounds as immunomodulatorsBDB
Incyte
Phosphonate linkers and their use to facilitate cellular retention of compoundsBDB
Merck Sharp & Dohme
Pyrazolo[1,5-a]pyrazin-4-yl derivativesBDB
Pfizer
Cyclic di-nucleotide compounds as sting agonistsBDB
Merck Sharp & Dohme
Small molecule activators of Parkin enzyme functionBDB
Mayo Foundation For Medical Education and Research
Therapeutic compounds and uses thereofBDB
Kala Pharmaceuticals
CRBN ligands and uses thereofBDB
Kymera Therapeutics
Alpha-truxillic acid derivatives and pharmaceutical compositions thereofBDB
The State University of New York
HDAC inhibitor compounds and methods of treatmentBDB
University of Florida Research Foundation
Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereofBDB
Jiangsu Hengrui Medicine
JAK inhibitors containing a 4-membered heterocyclic amideBDB
Theravance Biopharma R&D Ip
Spirocyclic sulfones as gamma secretase inhibitorsBDB
Merck Sharp & Dohme
6-substituted demethyl-estradiol derivatives as selective ER-β agonistsBDB
Endece
Pyrazolo[3,4-c]pyridine compounds and methods of useBDB
Genetech
Triazolyl PDE10 inhibitorsBDB
Merck Sharp & Dohme
Synthesis, Biological Evaluation, and Docking of Dihydropyrazole Sulfonamide Containing 2-hydroxyphenyl Moiety: A Series of Novel MMP-2 Inhibitors.BDB
Nanjing University
Pyrazolopyrimidine compounds and their use as PDE10 inhibitorsBDB
Mitsubishi Tanabe Pharma