46 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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The N-Terminal T-T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity.
Peking Union Medical College
Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein.
Ibitecs, Cea
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.
Bryn Mawr College
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.
Glaxosmithkline
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.
University of Illinois At Urbana-Champaign
Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity.
University of South Florida
Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.
Lindsley F. Kimball Research Institute
Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors.
Tokyo Medical and Dental University
Recent research results have converted gp120 binders to a therapeutic option for the treatment of HIV-1 infection. A medicinal chemistry point of view.
University of Siena
Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements.
Moscow State University
Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
University of Pennsylvania
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors.
Tokyo Medical and Dental University (Tmdu)
Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.
Nankai University
Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.
Cornell University
Soluble-type small-molecule CD4 mimics as HIV entry inhibitors.
Tokyo Medical and Dental University
Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
University of Pennsylvania
Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.
Touro University-California
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
Duke University Medical Center
De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.
Beijing Institute of Pharmacology and Toxicology
Synthesis and biological evaluation of water-soluble derivatives of chiral gossypol as HIV fusion inhibitors targeting gp41.
Renmin Hospital of Wuhan University
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir.
TBA
Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
Abbvie
Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
Array Biopharma
Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor ß/d (PPARß/d) in the brain.
Case Western Reserve University School of Medicine
Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi
Piramal Imaging
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
Merck Sharp & Dohme
Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.
Southern Research Institute
Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
Boehringer Ingelheim International
Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.
China Pharmaceutical University
Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
Novartis