65 articles for thisTarget
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Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.
Xi'An Jiaotong University
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.
University of Campinas
Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
University of Pittsburgh
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
Liaoning Normal University
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
Chinese Academy of Sciences
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
University of Paris
Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.
TBA
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.
Imperial College
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
University of Naples Federico II
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
University of Paris
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
The University of Tokyo
Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.
Yanbian University
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.
East China University of Science and Technology
Using small molecules to target protein phosphatases.
Max Planck Institute of Molecular Physiology
A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.
East China University of Science and Technology
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Chinese Academy of Sciences
5-Substituted [1]pyrindine derivatives with antiproliferative activity.
University of Paris
Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.
Sejong University
Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors.
Sejong University
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Virginia Polytechnic Institute and State University
Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.
Sejong University
Tetramic and tetronic acids: an update on new derivatives and biological aspects.
University of Bayreuth
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
Virginia Polytechnic Institute and State University
Fused Tetrahydroquinolines Are Interfering with Your Assay.
University of North Carolina at Chapel Hill
Microascones, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus
Chinese Academy of Sciences
Advances of bioorthogonal coupling reactions in drug development.
China Pharmaceutical University
Isosteviol derivatives as protein tyrosine Phosphatase-1B inhibitors: Synthesis, biological evaluation and molecular docking.
Shanghai Ocean University
Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.
Université
Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Graduate School of Chinese Academy of Sciences
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Korea Research Institute of Chemical Technology
Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
Iranian Fisheries Science Research Institute
Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue.
The University of Tokyo
Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.
The University of Tokyo
Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus
Chinese Academy of Sciences
Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B.
Shinshu University
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Korea Research Institute of Chemical Technology
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
University of Pittsburgh
Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition.
Tohoku University
Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.
University of Pittsburgh
The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity.
Pharmacia & Upjohn
Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25.
Mitotix
Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
Yanbian University College of Pharmacy
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.
Yanbian University
Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.
Montana State University
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Shandong University
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.
University of Naples Federico Ii
Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies.
King Abdulaziz University
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Sapienza University of Rome
2-aryl selenazole compound and pharmaceutical composition thereof
Jiangsu Atom Bioscience and Pharmaceutical
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
Pyridopyrimidine or pyrimidopyrimidine compound, prepration method, pharmaceutical composition, and use thereof
Shandong Luoxin Pharmaceutical Group Stock
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array Biopharma
Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
Novartis