Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 708K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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17 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Entremed

Structure-Activity Relationship Studies on Cell-Potent Nicotinamide

Purdue University

Potent Uncompetitive Inhibitors of Nicotinamide

Harvard University

Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.

Shionogi

Potent Inhibition of Nicotinamide

Leiden University

Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.

Shionogi

Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes.

Smith, Gambrell & Russell

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide

Biokin

Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.

Purdue University

Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide

TBA

Bisubstrate Inhibitors of Nicotinamide

Leiden University

Mechanisms and inhibitors of nicotinamide

Purdue University

Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.

The Scripps Research Institute

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

Sanofi-Aventis Deutschland

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Icahn School of Medicine At Mount Sinai

Methods for antagonizing a melanocortin 4 receptor

Pfizer

Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.

Egyptian Petroleum Research Institute