29 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
A potent and selective inhibitor targeting human and murine 12/15-LOX.
University of California
Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.
University of California
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.
Goethe-University Frankfurt
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
University Jena
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
National Institutes of Health
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.
University of Salerno
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
University of California Santa Cruz
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
University of California Santa Cruz
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
University of California
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
University of California
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.
Gazi University
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
National Human Genome Research Institute
Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.
University of Veterinary and Pharmaceutical Sciences Brno
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.
Merck Frosst Centre For Therapeutic Research
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
National Human Genome Research Institute
1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor
TBA
An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.
University of California
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.
Universidad De Santiago De Chile
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.
University of California
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
University of California
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
University of California Santa Cruz
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
University of California Santa Cruz
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
Abbott Laboratories
Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis.
UniversitäT Regensburg
