19 articles for thisTarget
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Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Warner-Lambert
Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models.
University of Alabama
Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel.
University of Alabama
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
TBA
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.
Institut Henri Beaufour
Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.
Pharmacia & Upjohn
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
The Scripps Research Institute
Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.
Cambridge Neuroscience
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects.
Institute For Bio-Medical Research
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.
Pharmacia & Upjohn
The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers.
Arqule
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.
Boehringer Ingelheim Pharma
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.
University of Alabama At Birmingham
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
Bial
Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.
University of Alabama At Birmingham
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations.
Howard University
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.
University of Alabama At Birmingham