48 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Selective Inhibitors of Human Liver Carboxylesterase Based on aß-Lapachone Scaffold: Novel Reagents for Reaction Profiling.
St. Jude Children'S Research Hospital
Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.
St. Jude Children'S Research Hospital
Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.
St. Jude Children'S Research Hospital
Synthesis and evaluation of colletoic acid core derivatives.
St. Jude Children'S Research Hospital
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
St. Jude Children'S Research Hospital
A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
St. Jude Children'S Research Hospital
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.
St. Jude Children'S Research Hospital
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.
St. Jude Children'S Research Hospital
Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.
St. Jude Children'S Research Hospital
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
St. Jude Children'S Research Hospital
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.
St. Jude Children'S Research Hospital
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.
St. Jude Children'S Research Hospital
Lead optimization of antimalarial propafenone analogues.
St. Jude Children'S Research Hospital
Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.
St. Jude Children'S Research Hospital
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
St. Jude Children'S Research Hospital
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.
St. Jude Children'S Research Hospital
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.
St. Jude Children'S Research Hospital
Optimization of propafenone analogues as antimalarial leads.
St. Jude Children'S Research Hospital
The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
St. Jude Children'S Research Hospital
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.
St. Jude Children'S Research Hospital
Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.
St. Jude Children'S Research Hospital
Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model.
St. Jude Children'S Research Hospital
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.
St. Jude Children'S Research Hospital
Design and synthesis of a novel tyrosine kinase inhibitor template.
St. Jude Children'S Research Hospital
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
St. Jude Children'S Research Hospital
Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations.
St. Jude Children'S Research Hospital
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.
St. Jude Children'S Research Hospital
Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
St. Jude Children'S Research Hospital
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
St. Jude Children'S Research Hospital
Recent Advances with KDM4 Inhibitors and Potential Applications.
St. Jude Children'S Research Hospital
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.
St. Jude Children'S Research Hospital
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.
St. Jude Children'S Research Hospital
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
St. Jude Children'S Research Hospital
Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70.
St. Jude Children'S Research Hospital
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
St. Jude Children'S Research Hospital
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
St. Jude Children'S Research Hospital
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
St. Jude Children'S Research Hospital
Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors.
St. Jude Children'S Research Hospital
Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").
St. Jude Children'S Research Hospital
Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
St. Jude Children'S Research Hospital
Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
St. Jude Children'S Research Hospital
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
St. Jude Children'S Research Hospital
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
St. Jude Children'S Research Hospital
