BDBM15157 1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one::pyrazinone 14d

SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1

InChI Key InChIKey=POLULYJEVDSBIB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15157   

TargetRAC-beta serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandPNGBDBM15157(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Affinity DataIC50: 5.41E+3nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandPNGBDBM15157(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Affinity DataIC50: 5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandPNGBDBM15157(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed