BDBM29840 spiro-carboxamide scaffold, 13

SMILES O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1

InChI Key InChIKey=KYTGICHJQRECNO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29840   

LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 377nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed