BDBM476660 (S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dibenzo[b,d]thiophen-2- yl)tetrahydropyrimidin-4(1H)-one::US10870635, Example 1

SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1

InChI Key InChIKey=NUBQUFYKLJMNAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 476660   

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660(US10870635, Example 1 | (S)-2-Imino-3,6-dimethyl-6...)
Affinity DataIC50: 26nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660(US10870635, Example 1 | (S)-2-Imino-3,6-dimethyl-6...)
Affinity DataIC50: 26nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetCathepsin D(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660(US10870635, Example 1 | (S)-2-Imino-3,6-dimethyl-6...)
Affinity DataIC50: 1.23E+4nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent