BDBM492621 US10980809, Example 17

SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(c4)S(C)(=O)=O)c(Cl)c3)c2c2OCCOc12

InChI Key InChIKey=HVUJIGWFYUNZNA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492621   

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492621(US10980809, Example 17)
Affinity DataIC50: 50nMAssay Description:1. Dilution of the compound: a total of 12 concentrations were obtained using a 4-fold gradient dilution from the highest concentration of 10000 nM (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492621(US10980809, Example 17)
Affinity DataIC50: 5.00E+3nMAssay Description:1. Preparation of test compounds: according to the molecular weight of the compounds, an appropriate volume of DMSO was directly added to dissolve th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492621(US10980809, Example 17)
Affinity DataIC50: 5.00E+3nMAssay Description:1. Preparation of test compounds: according to the molecular weight of the compounds, an appropriate volume of DMSO was directly added to dissolve th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent