BDBM50019170 2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one (20)::CHEMBL3289112

SMILES COc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=BDZQWMGYWFPJBN-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50019170   

TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 151nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in yeast cells using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBeta-glucuronidase(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetBeta-glucuronidase(Bovine)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate preincubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in yeast cells using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human CYP1A1 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin/7-ethoxy-methyloxy-3-cyanocoumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 expressed in yeast microsomal membranes using dibenzylfluorescein as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 expressed in yeast microsomal membranes using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetThymidine phosphorylase(Escherichia coli (strain SMS-3-5 / SECEC))
University of Karachi

LigandPNGBDBM50019170(CHEMBL3289112 | 2-(3'-Hydroxy-4'-methoxyph...)
Affinity DataIC50: 1.69E+5nMpH: 7.0Assay Description:TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 ยต...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed