BDBM50577251 CHEMBL4870637::US20240239774, Example 45

SMILES Cn1nc(c(Cc2ccccc2)c1CO)-c1cc(Cl)nc(N)n1

InChI Key InChIKey=HIQFTXNHVGRAOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50577251   

TargetAdenylate cyclase type 10(Human)
Cornell University

US Patent
LigandPNGBDBM50577251(CHEMBL4870637 | US20240239774, Example 45)
Affinity DataIC50: 400nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

TargetAdenylate cyclase type 10(Human)
Cornell University

US Patent
LigandPNGBDBM50577251(CHEMBL4870637 | US20240239774, Example 45)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human soluble adenylyl cyclase assessed as reduction in cAMP levels in the presence of alpha-32p labeled ATP by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed