BDBM50607675 CHEMBL5219922::US20240239774, Example 120

SMILES Cn1cc(Cc2ccccc2OCCN2CCNC(=O)C2)c(n1)-c1cc(Cl)nc(N)n1

InChI Key InChIKey=QHVCRPGFEZENTM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50607675   

TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607675(CHEMBL5219922 | US20240239774, Example 120)
Affinity DataIC50: 17nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607675(CHEMBL5219922 | US20240239774, Example 120)
Affinity DataIC50: 12nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent

TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607675(CHEMBL5219922 | US20240239774, Example 120)
Affinity DataIC50: 8nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent